CC did not affect IS in rats not receiving ATV. Statins are a common medication to lower cholesterol levels. ATV increased myocardial levels of Ser-473 phosphorylated Akt in the water + sugar and DC groups, but not in the CC group.ĬC, but not DC, abrogated the IS-limiting effects of ATV by blocking the adenosine receptors and preventing the phosphorylation of Akt. IS was 25.1 +/- 3.9% of the area at risk in the control group. Area at risk was assessed by blue dye and infarct size by TTC.īody weight and area at risk was comparable among groups. On the 4th day, rats were anesthetized and underwent 30 min of coronary artery occlusion and 4 h reperfusion. Here are some common medicines that may interact with grapefruit. Drinking water was replaced by water + sugar (7.5 g/100 ml), CC with sugar, or decaffeinated coffee (DC) with sugar. Lipitor) the common lipid-lowering statin drug is one of them. Rat received 3-day ATV (10 mg/kg/day) or water by oral gavage once daily. Caffeine is a nonspecific adenosine receptor blocker, and thus drinking CC may block the myocardial protective effects of statins. We asked whether caffeinated coffee (CC) blunts the infarct size (IS)-limiting effects of atorvastatin (ATV).Īdenosine receptor activation is essential for mediating the IS-limiting effects of statins.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |